Key Benefits
- Mitochondrial Enhancement & Metabolic Rewiring
- Activates ERRα, stabilizing its active form and boosting downstream mitochondrial pathways including OXPHOS, AMPK signaling, and fatty acid oxidation.
- Exercise-Mimicking Effects
- Induces features akin to aerobic exercise: increased oxidative muscle fibers and endurance, enhanced glucose uptake, and improved metabolic flexibility—even in sedentary animal models.
- Weight & Metabolic Syndrome Support
- Shown in mouse studies to reduce fat mass (by ~12–24%), improve insulin sensitivity, decrease hepatic steatosis, and enhance glucose tolerance.
- Cardiovascular & Organ Protection
- Demonstrated cardioprotective effects: preservation of contractility, reduced fibrosis, and better heart energy metabolism in models of heart injury or failure. Also reverses mitochondrial dysfunction and inflammation in aging tissues like the kidney.
Why It’s Unique
- Targets multiple ERR subtypes (α, β, γ) with highest potency at ERRα—acting as a balanced pan-ERR agonist.
Effectively delivers exercise-like metabolic signaling without physical activity, offering a compelling pathway for metabolic health optimization